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428 Relationship between Bone Age and Pubertal Breast Stage to Bone Biomarkers and Bone Mineral Density in Healthy Brazilian Female Adolescents
  1. TBL Goldberg1,
  2. CMT Fortes2,
  3. CS Kurokawa2,
  4. CC Silva3,
  5. MR Moretto2,
  6. HRDC Nunes4
  1. 1Department of Pediatrics, Post Graduation Program in Gynecology, Obstetrics and Mastology
  2. 2Department of Pediatrics, Clinical and Experimental Pediatric Research Center, Botucatu School of Medicine, São Paulo State University - UNESP, Botucatu
  3. 3Department of Physical Education, University of North Paraná, Jacarezinho
  4. 4Statistical Consultant, Botucatu School of Medicine, São Paulo State University - UNESP, Botucatu, Brazil


Background and Aims Bone metabolism involves understanding many factors, especially during puberty, when bone turnover is significant and the bone mass peak must be achieved as a protective factor of future bone health. The objective was to evaluate the behavior of formation and resorption bone biomarkers (BB) in function of biological maturation in female adolescents.

Methods Evaluation of formation and resorption BB, osteocalcin (OC), bone alkaline phosphatase (BAP) and carboxyterminal telopeptide (S-CTx) by correlating them with bone mineralization, bone age and pubertal development in healthy female adolescents. Seventy-two volunteers were subdivided into groups according to chronological age/bone age (BA): 10–11 years (n=12), 12–13 years (n=16), 14–15 years (n=15) and 16–19 years (n=29). The following were evaluated: weight (kg), height (m), BMI (kg/m2), calcium intake (3-day 24h food recalls (mg/day), puberty events (Tanner stages), serum OC (ng/mL), BAP (U/L), S-CTx (ng/mL) and bone mineral density (BMD) as calculated by DXA (g/cm2) in the spine (L1-L4), proximal femur and whole body. The project was approved by the UNESP Ethics Committee.

Results BB showed similar behaviors, with higher mean values for 10–12 years and when adolescents were in the B2-B3 Pubertal Maturation Stage (B2: BAP=110.16 U/L, OC=33.81ng/mL, S-CTx=1.66 ng/mL and B3: BAP=136.50 U/L, OC=39.15ng/mL and S-CTx=1.88 ng/mL; p<0.001). Mean BB values decreased with advancing BA and pubertal maturity.

Conclusions BB values showed parallelism with peak height velocity and significant negative correlation with BMD in the different evaluated sites, with chronological and BA ; higher BMD values correlated with lower bone biomarker values.

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