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44 Comparison of the Efficacy of C-Reactive Protein, Procalcitonin, Interleukin-6 Levels and New Leukocyte Parameters in the Diagnosis of Neonatal Sepsis
  1. T Çelik1,
  2. O Portakal2,
  3. Ş Yiğit1,
  4. G Hasçelik3,
  5. A Korkmaz1,
  6. M Yurdakök1
  1. 1Department of Pediatrics, Division of Neonatology, Hacettepe University, Faculty of Medicine
  2. 2Department of Biochemistry
  3. 3Department of Microbiology, Hacetepe University, Faculty of Medicine, Ankara, Turkey

Abstract

Background and aims Sepsis is an important cause of morbidity and mortality among newborn infants. Blood culture is the gold standard. Early and definitive diagnosis of neonatal sepsis is difficult because its sings and symptoms are nonspecific. New leukocyte parameters such as neutrophil volume (MNV), conductivity (MNC), scattering (MNS) and volume distribution width (NDW) were introduced in the diagnosis of sepsis recently. We aimed to investigate these parameters in newborn sepsis and compare their efficacy with serum CRP, Procalcitonin (PCT), IL-6 levels.

Methods This study was conducted in Hacettepe University Neonatology Unit, between July 2010 and February 2012. Total 227 newborns, 116 sepsis (40 proven, 76 clinical sepsis) and 111 control included in the study.

Results Results are summarized in the Table 1.

Abstract 44 Table 1

Conclusions In conclusion new CBC parameters can be helpful in differential diagnosis of newborn sepsis in addition to other screening parameters. MNV seems the most useful parameter with the highest spesifity.

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