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Validation of JADAS in all ILAR subtypes of juvenile idiopathic arthritis (JIA) in the clinical setting
  1. F McErlane1,2,
  2. MW Beresford2,3,
  3. EM Baildam3,
  4. W Thomson1,
  5. K Hyrich1,
  6. A Chieng4,
  7. J Davidson5,
  8. HE Foster6,
  9. J Gardner-Medwin5,
  10. M Lunt1,
  11. L Wedderburn7
  1. 1School of Translational Medicine, University of Manchester, Manchester, UK
  2. 2Institute of Child Health, University of Liverpool, Liverpool, UK
  3. 3Paediatric Rheumatology, Alder Hey Children's Hospital, Liverpool, UK
  4. 4Rheumatology, Royal Manchester Children's Hospital, Manchester, UK
  5. 5Rheumatology, Royal Hospital for Sick Children, Glasgow, UK
  6. 6Rheumatology, Newcastle Medical School, Newcastle-upon-Tyne, UK
  7. 7Rheumatology Unit, Institute of Child health, London, UK

Abstract

Background Juvenile Arthritis Disease Activity Score (JADAS) is a 4 variable composite disease activity (DA) score for JIA (including active 10, 27 or 71 joint count (AJC), physician global (PGA), parent/child global (PGE) and ESR). The validity of JADAS for all ILAR subtypes in the routine clinical setting is unknown. We investigated the construct validity of JADAS in the clinical setting in all subtypes of JIA through application to a prospective inception cohort of UK children presenting with new onset inflammatory arthritis.

Methods JADAS 10, 27 and 71 were determined for all children in the Childhood Arthritis Prospective Study (CAPS) with complete data available at baseline. Correlation of JADAS 10, 27 and 71 with single DA markers was determined for all subtypes using Spearman's rank statistic.

Results 262/1238 visits had sufficient data for calculation of JADAS (1028 (83%) AJC, 744 (60%) PGA, 843 (68%) PGE and 459 (37%) ESR). Median age at disease onset was 6.0 years (IQR 2.6-10.4) and 64% were female.

Correlation between JADAS 10, 27 and 71 approached 1 for all subtypes. Median JADAS 71 was 5.3 (IQR 2.2-10.1) with a significant difference between median JADAS scores between subtypes (p<0.01).

Correlation of JADAS 71 with each single marker of DA was moderate to high in the total cohort. (AJC r2 = 0.59, PGA r2=0.64, PGE r2=0.61, ESR r2=0.53, limited JC r2=0.41, parental pain r2=0.53, CHAQ r2=0.47). Overall, correlation with AJC, PGA and PGE was moderate to high and correlation with ESR, limited JC, parental pain and CHAQ was low to moderate in the individual subtypes. Correlation coefficients in the extended oligoarticular, rheumatoid factor negative and enthesitis related subtypes should be interpreted with caution in view of low numbers.

Conclusions This study adds to the body of evidence supporting the construct validity of JADAS. JADAS correlates with other measures of DA in all ILAR subtypes in the routine clinical setting. Given the high frequency of missing ESR data, it would be useful to assess the validity of JADAS without inclusion of the ESR.

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