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A randomised controlled trial of Hartmann's solution versus half normal saline in postoperative paediatric spinal instrumentation and craniotomy patients
  1. Mark G Coulthard1,2,
  2. Debbie A Long2,
  3. Amanda J Ullman2,
  4. Robert S Ware3,4
  1. 1Academic Discipline of Paediatrics and Child Health, University of Queensland, Brisbane, Australia
  2. 2Paediatric Intensive Care Unit, Royal Children's Hospital, Herston, Brisbane, Australia
  3. 3School of Population Health, University of Queensland, Brisbane, Australia
  4. 4Queensland Children's Medical Research Institute, Herston, Queensland 4029, Australia
  1. Correspondence to Mark G Coulthard, Academic Discipline of Paediatrics and Child Health, University of Queensland, Herston, QLD 4029, Australia; Mark_Coulthard{at}health.qld.gov.au

Abstract

Objective To compare the difference in plasma sodium at 16–18 h following major surgery in children who were prescribed either Hartmann's and 5% dextrose or 0.45% saline and 5% dextrose.

Design A prospective, randomised, open label study.

Setting The paediatric intensive care unit (650 admissions per annum) in a tertiary children's hospital in Brisbane, Australia.

Patients The study group comprised 82 children undergoing spinal instrumentation, craniotomy for brain tumour resection, or cranial vault remodelling.

Interventions Patients received either Hartmann's and 5% dextrose at full maintenance rate or 0.45% saline and 5% dextrose at two-thirds maintenance rate.

Main outcomes measures Primary outcome measure: plasma sodium at 16–18 h postoperatively; secondary outcome measure: number of fluid boluses administered.

Results Mean postoperative plasma sodium levels of children receiving 0.45% saline and 5% dextrose were 1.4 mmol/l (95% CI 0.4 to 2.5) lower than those receiving Hartmann's and 5% dextrose (p=0.008). In the 0.45% saline group, seven patients (18%) became hyponatraemic (Na <135 mmol/l) at 16–18 h postoperatively; in the Hartmann's group no patient became hyponatraemic (p=0.01). No child in either fluid group became hypernatraemic.

Conclusions The postoperative fall in plasma sodium was smaller in children who received Hartmann's and 5% dextrose compared to those who received 0.45% saline and 5% dextrose. It is suggested that Hartmann's and 5% dextrose should be administered at full maintenance rate postoperatively to children who have undergone major surgery in preference to hypotonic fluids.

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Footnotes

  • Competing interests None.

  • Ethics approval The study received approval from the Human Research Ethics Committee of the Royal Children's Hospital, Brisbane, and was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12607000116426).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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