Question 2 What is the ideal dose of vitamin D supplementation for term neonates?
- Chike Onwuneme1,2,4,
- Aoife Carroll2,
- Roberta McCarthy1,
- Mark Kilbane3,
- Malachi McKenna3,
- Nuala Murphy2,
- Eleanor J Molloy1,4,5
- 1Department of Paediatrics, National Maternity Hospital, Dublin, Ireland
- 2Department of Endocrinology, Children's University Hospital Temple Street, Dublin, Ireland
- 3Metabolism Laboratory, St Vincent's University Hospital, Dublin, Ireland
- 4UCD School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
- 5Department of Neonatology, National Maternity Hospital, Dublin, Ireland
- Correspondence to Chike Onwuneme, Department of Paediatrics, National Maternity Hospital, Holles Street, Dublin 2, Ireland;
- Received 25 January 2012
- Accepted 29 January 2012
During a well-baby check, a mother asked for the consultant's recommendation on the ideal dose and type of vitamin D formulation for her infant. She intends to breastfeed her baby exclusively. Her baby was born at 39 weeks gestation by spontaneous vaginal delivery.
Structured clinical question
In a normal term neonate [patient], what is the optimal dose of vitamin D supplementation [intervention] to prevent vitamin D deficiency and rickets [outcome]?
MEDLINE was searched via PubMed from 1990 to July 2011. The advanced search mode was used with the terms ‘vitamin D’ and ‘neonates’ and ‘supplementation’.
A search of the Cochrane Library was conducted using the search terms ‘vitamin D’ and ‘infants’.
Vitamin D is essential for good bone health and insufficient levels are linked to rickets in children.1 5 A resurgence of vitamin D insufficiency and nutritional rickets has been reported across many countries.1 Studies in infants and children are also exploring the association between vitamin D insufficiency and type 1 diabetes mellitus as well as inflammatory diseases.1 2 There …