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Heated humidified high flow nasal cannula (HHHFNC) therapy is becoming increasingly used in preterm infants and there is evidence that it can provide some degree of respiratory support.1 2 We designed a prospective, randomised, open pilot study to assess the safety and feasibility of using HHHFNC therapy in infants with bronchiolitis.
We recruited infants with a clinical diagnosis of moderately severe bronchiolitis. Following parental informed consent, infants were randomised to head-box oxygen or the Vapotherm 2000i (Vapotherm Inc, Stevensville, Maryland, USA). Initial vapotherm flow was 4 l/min with 100% oxygen and was increased up to 8 l/min if tolerated. Oxygen concentration was adjusted in both groups to achieve target pulse …