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Sleep quality and nocturnal hypoxaemia and hypercapnia in children and young adults with cystic fibrosis
  1. Brigitte Fauroux1,
  2. Jean-Louis Pepin2,
  3. Pierre-Yves Boelle3,
  4. Claire Cracowski4,
  5. Marlène Murris-Espin5,
  6. Raphaele Nove-Josserand6,
  7. Nathalie Stremler7,
  8. Tabassome Simon8,
  9. Pierre-Régis Burgel9
  1. 1Pediatric Pulmonary Department, AP-HP, Hôpital Armand Trousseau, CRCM Enfant, Université Pierre et Marie Curie – Paris 6, INSERM U 955, Paris, France
  2. 2Department of Physiology and Rehabilitation, INSERM ERI17, HP2 Laboratory (Hypoxia: Pathophysiology), Grenoble University Hospital, Grenoble, France
  3. 3Biostatistic Department, Université Pierre et Marie Curie – Paris 6, AP-HP, Hôpital Saint Antoine, INSERM UMR-S 707, Paris, France
  4. 4Pole de Medecine aigue Communautaire, Grenoble University Hospital, Grenoble, France
  5. 5Pôle des Voies Respiratoires, CRCM Adulte, Hôpital Larrey, Hôpitaux de Toulouse, Paris, France
  6. 6CRCM Adulte, CH Lyon Sud, Lyon, Pierre-Bénite, France
  7. 7Pediatric Department, CRCM Timone-Enfants, Hôpital La Timone, Marseille, France
  8. 8URC Est, AP-HP, Hôpital Saint Antoine, Université Pierre et Marie Curie – Paris 6, Paris, France
  9. 9Pulmonary Department, AP-HP, Hôpital Cochin, University Paris Descartes, Paris, France
  1. Correspondence to Dr Brigitte Fauroux, AP-HP, Pediatric Pulmonary Department, Hôpital Armand Trousseau, Université Pierre et Marie Curie – Paris 6, INSERM U 955, 28 avenue du Docteur Arnold Netter, Paris F-75012, France; brigitte.fauroux{at}trs.aphp.fr

Abstract

Objectives The aim of the study was to evaluate sleep quality and nocturnal gas exchange in patients with cystic fibrosis (CF) and to assess if sleep quality and daytime lung function could predict nocturnal hypoxaemia or hypercapnia.

Study design Daytime sleepiness and objective sleep quality were evaluated by the Pittsburgh Sleep Quality Index (PSQI) and actigraphy in 25 children and 55 young adults (mean age 24±10 years, forced expiratory volume in 1 s (FEV1) 41±11% predicted). Nocturnal gas exchange was assessed by pulse oximetry (SpO2) and transcutaneous carbon dioxide (PtcCO2) recordings. Eleven patients underwent simultaneous polysomnography (PSG).

Results PSQI was 6.3±3.4 with 51% of the patients having a score >5 corresponding to significant sleep complaints. On actigraphy, sleep efficiency was impaired at 79±11% with a fragmentation index at 41±18. Mean nocturnal SpO2 was 93±3% with 18% of the patients exhibiting >10% of night time spent with a value below 90%. Mean PtcCO2 was 44±6 mm Hg with 47% of the patients exhibiting >10% of night time with a value >45 mm Hg. Daytime arterial blood gases correlated with nocturnal gas exchange. FEV1 was the only lung function parameter that correlated with nocturnal SpO2 (p<0.01). Compared with PSG, SpO2 and PtcCO2 accurately identified rapid eye movement sleep hypoventilation.

Conclusions Patients with CF exhibit poor sleep quality that does not predict nocturnal gas exchange. Nocturnal hypoxaemia and hypercapnia can be identified by simple tools.

  • Sleep
  • Cystic Fibrosis

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