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Haemoglobin H disease in California

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Haemoglobin (Hb) H disease is a form of α-thalassaemia prevalent among Asian and Mediterranean people. In its usual (deletional) form, three of the four α-globulin loci are missing and patients have a mixture of HbH and HbA with some HbA2. Asian immigration has led to an increase in the prevalence of HbH disease on the west coast of …

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