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Arch Dis Child 96:1175-1179 doi:10.1136/archdischild-2011-300424
  • Drug therapy

Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone

Table 2

Definitions of significant temperature

Study Definitions
Erlewyn-Lajeunesse et al14 Difference of 1°C at 1 h clinically significant
Nabulsi et al13 Normal temperature 36.5–37.9°C
Sarrell et al11 Afebrile if <37.8°C
Hay et al10 Time without fever <37.2°C
Kramer et al12 Fever if >38°C
Paul et al15 38°C standard temperature threshold used by schools and day-care for exclusion

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