With the decline of rheumatic fever, Kawasaki disease is now the most common cause of acquired heart disease in childhood in developed countries, including the United Kingdom. There has been evidence from several countries of an increasing incidence of Kawasaki disease. About 85% of cases are in children under the age of 5 years. The aetiology is unknown, although epidemiological evidence points to one or more infectious causes with geographical and temporal clustering, seasonal variation, and the involvement of genetic factors. Data …