Nutritional recovery in HIV-infected and HIV-uninfected children with severe acute malnutrition
- 1Liverpool School of Tropical Medicine, Liverpool, UK
- 2Action Against Hunger UK, London, UK
- 3Action Against Hunger Malawi, Lilongwe, Malawi
- 4Centre for International Health and Development, Institute of Child Health, London, UK
- 5Ministry of Health, Lilongwe, Malawi
- Pamela Fergusson, Liverpool School of Tropical Medicine, Disease Control Group, Pembroke Place, Liverpool L3 5QA, UK;
- Revised 13 October 2008
- Published Online First 31 October 2008
Objective: Few studies have reported on nutritional recovery, survival and growth among severely malnourished children with HIV. This study explores nutritional recovery in HIV-infected and HIV-uninfected children during inpatient nutrition rehabilitation and 4 months of follow-up.
Design: Prospective cohort study.
Setting: Lilongwe district, Malawi.
Main outcome measures: Weight gain, anthropometrics.
Results: In our sample of 454 children with severe acute malnutrition (SAM), 17.4% (n = 79) of children were HIV infected. None of the children were on antiretroviral therapy upon admission. Among the HIV-infected children, 35.4% (28/79) died, compared with 10.4% (39/375) in HIV-uninfected children (p<0.001). All children who survived achieved nutritional recovery (>85% weight for height and no oedema), regardless of HIV status. HIV-infected children had similar weight gain to HIV-uninfected children (8.9 vs 8.0 g/kg/d, not significant (NS)). Mean increases in z-scores for both subscapular (2.72 vs 2.69, NS) and triceps (1.26 vs 1.48, NS) skinfolds were similar between HIV-infected and HIV-uninfected children, respectively, during nutrition rehabilitation. 362 children were followed for 4 months, at which time mean weight for height z-score was similar in HIV-infected and HIV-uninfected children (−0.85 vs −0.64, NS).
Conclusions: HIV-infected children with SAM have higher mortality rates than HIV-uninfected children. Among those who survive, however, nutritional recovery is similar in HIV-infected and HIV-uninfected children.
Competing interests: None.
Ethics approval: Ethical approval was given by the National Health Sciences Research Committee of Malawi.
Patient consent: Parental consent obtained.