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Effect of adenoidectomy on respiratory function: a randomised prospective study
  1. P S Mattila1,
  2. S Hammarén-Malmi1,
  3. A S Pelkonen2,
  4. L P Malmberg2,
  5. M J Mäkelä2,
  6. H Saxen3,
  7. J Tarkkanen4
  1. 1
    Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
  2. 2
    Department of Allergy, Helsinki University Central Hospital, Helsinki, Finland
  3. 3
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
  4. 4
    Department of Pathology, HUSLAB, Helsinki University Central Hospital and Haartman Institute, University of Helsinki, Helsinki, Finland
  1. Petri S Mattila, Department of Otorhinolaryngology, Helsinki University Central Hospital, Haartmaninkatu 4 E, PO Box 220, 00290 Helsinki, Finland; petri.mattila{at}hus.fi

Abstract

Objective: Risk of childhood asthma is increased in children with recurrent otitis media. This may be associated with recurrent respiratory tract infections in these children, but the role of adenoidectomy, a frequent operation during childhood, is unknown. Therefore, the role of adenoidectomy in the development of atopy and respiratory function changes characteristic of asthma was evaluated.

Design: Randomised controlled study.

Setting: Tertiary care centre.

Patients: 166 children aged 12–48 months who had recurrent or persistent otitis media and who were followed-up for 3 years after randomisation.

Intervention: Randomisation to undergo insertion of tympanostomy tubes with or without adenoidectomy.

Main outcome measures: The primary outcome measure was exercise-induced bronchoconstriction as evaluated by impulse oscillometry. The secondary outcome measures were bronchial inflammation as evaluated by exhaled nitric oxide and atopy as evaluated by skin prick tests. During the 3-year follow-up period otitis media episodes were documented in patient diaries.

Results: Adenoidectomy did not significantly influence baseline lung function, exercise-induced bronchoconstriction, exhaled nitric oxide concentration, the development of positive skin prick tests, or doctor-diagnosed asthma. Adenoidectomy did not significantly prevent otitis media. Recurrent otitis media (⩾4 episodes) during the first follow-up year was associated with an abnormal exercise-induced bronchoconstriction (OR 6.62, 95% CI 1.27 to 34) and an elevated exhaled nitric oxide concentration (OR 3.26, 95% CI 0.98 to 10.8) regardless of adenoidectomy.

Conclusions: Adenoidectomy did not promote asthma or allergy. Recurrent respiratory tract infections during early childhood are associated with the risk of bronchial hyper-reactivity.

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Footnotes

  • Competing interests: None.

  • Funding: This work received financial support from the Helsinki University Central Hospital Research Funds, Allergy Research Foundation and Sigrid Juselius Foundation.

  • Ethics approval: The Ethics Review Committee of Helsinki University Central Hospital approved the study.

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