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QUESTION 3
  1. Fyeza Hasan
  1. Molecular Haematology and Cancer Biology Unit, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK; fyezahasan@hotmail.com

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    DOES DAILY PREDNISOLONE REDUCE THE RISK OF RELAPSE SECONDARY TO VIRAL INFECTIONS IN STEROID-DEPENDENT NEPHROTIC SYNDROME?

    A 4-year-old boy with steroid-dependent minimal change disease has symptoms of a viral upper respiratory tract infection (URTI). Will changing from alternate daily to daily steroids reduce the risk that this infection will provoke a relapse?

    Structured clinical question

    In a child with steroid-dependent nephrotic syndrome on alternate daily prednisolone with a viral upper respiratory tract infection [patient], does changing to daily steroids [intervention] compared to placebo or continuing alternate daily prednisolone [comparison] reduce the risk of relapse [outcome]?

    Search strategy and outcome

    Searches were carried out in March 2008. Search terms were (“corticosteroids” …

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