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The WAGR syndrome, brain-derived neurotrophic factor and obesity

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Population changes in the prevalence of obesity are largely determined by lifestyle changes (overeating and lack of exercise), but at a personal level genetic factors influence the ease with which people respond to lifestyle factors by becoming obese. Single gene mutations affecting the hypothalamic leptin-melanocortin pathway account for only 2% of cases of childhood obesity, but whole genome studies have shown that single nucleotide …

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