Article Text

HELICOBACTER PYLORI INFECTION: RELATION TO PROTEIN LOSING ENTEROPATHY IN MALNUTRITION
  1. S H Barakat1,
  2. E H Madina1,
  3. W El-Neanaey2,
  4. R Sayed1
  1. 1Department of Pediatrics, Faculty of Medicine, University of Alexandria, Alexandria, Egypt
  2. 2Department of Clinical Pathology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt

Abstract

Objectives To study the prevalence of Helicobacter pylori (H-P) infection in malnourished children and to prove the association—if any—between H-P infection and protein losing enteropathy (PLE) in these children.

Methods Stool samples of 100 studied children (40 underweight children, 40 marasmic children and 20 age- and sex-matched, well nourished children as a control group) were tested for H-P antigen and feacal concentration of alpha 1-antitrypsin (FA-AT) using ELISA technique. Estimation of both parameters was repeated in H-P positive children 6 weeks after eradication therapy of H-P infection.

Results The prevalence of H-P infection was detected in 66% of malnourished children compared to 20% of control group. Malnourished children (either H-P positive or negative) had significantly higher FA-AT when compared to control group (P = 0.0001). The mean values of FA-AT were significantly higher in malnourished H-P positive children than in those with negative infection (P⩽0.0001), and after eradication of H-P infection, the mean values of FA-AT showed a significant decrease (P⩽0.0001). However, these values were still higher than in control group (P⩽0.0001).

Conclusions H-P infection has a high prevalence in malnourished children and may be an important co-factor in the etiology of some aspects of protein energy malnutrition and has a leading role in the pathogenesis of PLE.

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