Article Text

IS THE PROGNOSTIC VALUE OF EARLY AMPLITUDE INTEGRATED EEG ALTERED IN ASPHYXIATED INFANTS UNDERGOING SYSTEMIC HYPOTHERMIA?
  1. K Robertson Grossmann2,
  2. B Hallberg2,
  3. M Bartocci1,
  4. L Olson1,
  5. M Blennow2
  1. 1Institution of Women and Child Health, Karolinska Institute, Stockholm, Sweden
  2. 2Institution CLINTEC, Karolinska Institute, Stockholm, Sweden

Abstract

Objective This study aims to investigate the correlation between amplitude integrated EEG (aEEG) at 6 and 24 h post partum, magnetic resonance imaging (MRI) findings and short-term outcome in full-term infants treated with systemic hypothermia after perinatal asphyxia and moderate/severe hypoxic–ischaemic encephalopathy (HIE).

Methods Between December 2006 and December 2007, 24 infants with HIE were treated with systemic hypothermia (body temperature 33–34°C for 72 h) according to national guidelines, using a Thecoterm device. aEEG was continuously monitored and the level of encephalopathy assessed. Brain MRI was conducted within the first 2 weeks. Follow-up of motor functions according to the Alberta infant motor scale (defined as normal/mild–severe dysfunction) and behavioural function was carried out at 1, 4, 6 and 12 months.

Results aEEG data were available from 17 neonates. At 6 h 12 infants exhibited a severely abnormal burst-suppression pattern. Only four infants had persisting burst-suppression at 24 h. A continuous/discontinuous normal voltage pattern was observed in five and 13 infants at 6 and 24 h, respectively (see table).

Robertson Grossman et al

Conclusions Severe aEEG abnormalities were found to normalise within the first 24 h in two-thirds of the infants. The prognostic value of early aEEG might be altered in infants undergoing systemic hypothermia.

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