Article Text

LENTICULOSTRIATE VASCULOPATHY: INCIDENCE AND ASSOCIATION WITH CLINICAL PARAMETERS IN PRETERM NEONATES
  1. L M Leijser1,
  2. S J Steggerda1,
  3. F T de Bruine2,
  4. J van der Grond2,
  5. F J Walther1,
  6. G van Wezel-Meijler1
  1. 1Division of Neonatology, Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands
  2. 2Division of Neuroradiology, Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands

Abstract

Objective Lenticulostriate vasculopathy (LSV) can be seen on neonatal cranial ultrasound scans (cUS). It has been associated with various clinical conditions. Studies in preterm infants are limited. Our aim was to evaluate for LSV in very preterm (VPT) infants <32 weeks: incidence, characteristics, association with clinical parameters, aetiology, magnetic resonance imaging (MRI) equivalent.

Methods In VPT sequential cUS were performed from birth until term and evaluated for LSV and other cerebral abnormalities. The incidence of LSV and various clinical parameters were calculated. Term MRI was assessed for deep grey matter changes.

Results In 24/129 VPT (19%; 10 of multiple births) LSV was encountered. Mean gestational age and weight at birth were 28.7 weeks and 1175 g. Mean postnatal ages when LSV was first and last seen were 27 and 81 days, respectively; mean total duration was 60 days. In three infants (all twins) it was seen at birth and in 17 still at term. It was unilateral in 17 infants and bilateral in seven, and appeared punctate in three, linear in 14 and branching in seven. It was associated with female gender (p = 0.02) and negatively associated with hypotension (p = 0.04). No deep grey matter changes were seen on MRI.

Conclusions LSV was frequently seen on sequential cUS in VPT infants and was mostly unilateral, linear, and first seen several weeks after birth. It was associated with multiple birth and female gender and negatively associated with hypotension. No MRI equivalent was found. Further study is needed to assess the origin and implications of LSV.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.