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CARDIAC TROPONIN T AND N-TERMINAL PRO-B TYPE NATRIURETIC PEPTIDE REFLECT MYOCARDIAL FUNCTION IN PRETERM INFANTS
  1. A F EL-Khuffash1,2,
  2. P G Davis3,
  3. K Walsh4,
  4. E J Molloy1,2,3
  1. 1Department of Neonatology, National Maternity Hospital, Dublin, Ireland
  2. 2School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
  3. 3Neonatal Services, Royal Women’s Hospital, Carlton, Australia
  4. 4Our Lady’s Hospital for Sick Children, Dublin, Ireland

Abstract

Background Cardiovascular compromise is increasingly recognised in preterm infants. Currently, echocardiography is the best tool to assess myocardial contractility and guide management. Elevated levels of cardiac troponin T (cTnT) and N-terminal-pro-B type natriuretic peptide (NTpBNP) are associated with poor myocardial contractility and low cardiac output in adults.

Aims To examine the range of cTnT and NTpBNP in preterm infants, to correlate NTpBNP and cTnT with echocardiographic markers of cardiac function and to assess the influence of antenatal and postnatal factors on these biochemical markers.

Methods Plasma concentrations of cTnT and NTpBNP were measured in infants <1500 g at 12 h of age. These were correlated with simultaneous echocardiographic measures of myocardial function and output. Antenatal data, infant demographics and postnatal characteristics were prospectively recorded.

Results A total of 80 infants had samples taken and echocardiography performed. Their median (interquartile range) cTnT and NTpBNP values were 0.20 μg/l (0.11–0.40) and 1273 pmol/l (664–2798), respectively. There was a significant inverse correlation between cTnT and echocardiographic markers of myocardial function and stroke volume. NTpBNP significantly correlated with the LA : Ao ratio. There was a weaker but significant negative correlation between NTpBNP and left ventricular function. The assays were not influenced by gestation, birth weight, gender, or mode of delivery.

Conclusions cTnT and NTpBNP correlated with echocardiographic measures of cardiac performance in preterm infants. Measurement of levels in the first hours of life may provide useful information regarding myocardial function and volume loading.

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