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CHARACTERISTICS AND RESPIRATORY OUTCOMES OF INFANTS WITH BRONCHOPULMONARY DYSPLASIA
  1. F R Moya1,
  2. C G Guardia2,
  3. A Maturana3
  1. 1Department of Neonatology, Coastal Area Health Education Center, Wilmington, North Carolina, USA
  2. 2Discovery Laboratories Inc, Warrington, Pennsylvania, USA
  3. 3Universidad del Desarrollo, Santiago, Chile

Abstract

Background Newer, atypical forms of bronchopulmonary dysplasia (BPD) have been described, which differ from the classic BPD.

Objective To describe the incidence and long-term respiratory outcomes of classic BPD and newer BPD in SELECT (Pediatrics, 2005).

Methods Of 1294 infants enrolled in SELECT, 26% (N  =  258) had BPD at 36 weeks post-menstrual age. Two groups were constructed based on daily means of FiO2 : classic BPD (respiratory distress syndrome (RDS) not resolved): FiO2 >25% between 48 and 72 h and continuous FiO2 >30% for >28 days. Newer BPD (no RDS or RDS resolved): FiO2 <5% between 48 and 72 h with no oxygen or requirement <25% for >7 days. Days on mechanical ventilation, days on oxygen and respiratory illnesses data were obtained through 12 months continuous assessment.

Results Newer BPD accounted for 46% and classic BPD for 54%. There were no differences in baseline demographics or in median of days on mechanical ventilation or oxygen. Infants with newer BPD required lower FiO2 (fig). The incidence of respiratory illnesses was higher in infants with classic BPD (66% vs 83%).

Figure 1

Moya et al BPD, bronchopulmonary dysplasia.

Conclusions Milder forms accounted for close to 50% of BPD. Birth weight and gestational age were similar between groups. The more severe presentation of BPD in infants with classic BPD suggests a worse long-term respiratory outcome.

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