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CORRELATIONS BETWEEN CIS AND TRANS FATTY ACIDS IN HUMAN MILK BOTH AT THE 6TH WEEK AND 6TH MONTH OF LACTATION
  1. E Szabo1,
  2. G Boehm2,3,
  3. C Beermann2,
  4. M Weyermann4,
  5. H Brenner4,
  6. D Rothenbacher4,
  7. T Decsi1
  1. 1Department of Paediatrics, University of Pecs, Pecs, Hungary
  2. 2Danone Research, Center for Specialised Nutrition, Friedrichsdorf, Germany
  3. 3Sophia Children’s Hospital, Erasmus University, Rotterdam, The Netherlands
  4. 4Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany

Abstract

Aim To investigate the association between trans isomeric and polyunsaturated fatty acids (PUFAs) in human milk samples determined in a large cohort of lactating mothers.

Methods Human milk samples of mothers participating in a large birth cohort study in Germany were investigated both at the 6th week (n = 769, age: 31.4 [4.8] years, BMI at the beginning of pregnancy: 23.3 [3.7] kg/m2) and at the 6th month of lactation (n = 462). Fatty acid composition of milk samples was determined by high-resolution capillary gas chromatography.

Results We found no inverse correlations between trans hexadecenoic acid (C16:1n-7t) and linoleic acid (C18:2n-6), arachidonic acid (C20:4n-6), alpha-linolenic acid (C18:3n-3) and docosahexaenoic acid (C22:6n-3). In contrast, there were almost uniformly significant inverse correlations between trans octadecenoic acid (C18:1n-7/9t) and the sum of trans isomeric fatty acids and the investigated n-3 and n-6 PUFAs both at the 6th week and the 6th month of lactation (table).

Conclusion

Szabo et al Spearman rho correlation coefficients in milk samples in German mothers both at the 6th week and at the 6th month of lactation (*p<0.05 **p<0.01, ***p<0.0001)

Our results suggest that trans isomeric fatty acids may interfere with the availability of essential fatty acids and arachidonic acid in mature human milk not only at the 6th week, but even at the 6th month of lactation.

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