Article Text

COMPARISON OF EFFECTS AND SIDE EFFECTS OF ACETAMINOPHEN AND IBUPROFEN IN THE MANAGEMENT OF FEBRILE CHILDREN
  1. S Ebrahimi1,
  2. H Gaffarian2,
  3. M Shahamat3
  1. 1Department of Pediatrics, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
  2. 2Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
  3. 3Imam Sajjad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran

Abstract

Fever is one of the most common symptoms of disease in children.

In this double blind randomised clinical trial study, patients tended to range in age from about 0.5 to 12 years, and to have initial body temperatures from 38 to 40.5°C. Selected patients were randomly allocated to one of two groups of trial and control. Temperature was recorded before medication and then patients in the trial group were given ibuprofen (10 mg/kg) and other patients were given acetaminophen (10 mg/kg); temperature was controlled in intervals of 0.5–1–2–3–4 h after medication and patients were observed for 24 h. Then the data were recorded.

The average body temperature in children who received acetaminophen was 38.75°C and in children who received ibuprofen 38.6°C; the difference between the two groups was not statistically significant. It was found that in intervals of 0.5–1–2–3–4 h, acetaminophen reduced 0.7–1.06–1.37–1.49–1.59 and ibuprofen reduced 0.8–1.24–1.54–1.64–1.66 of paediatric body temperature. Consideration with the t-test showed the differences to be statistically significant. Vomiting as a side effect in the case group was 11% and in the control group was 1%. Diarrhoea in the case group was 5% and was not seen in the control group. Abdominal pain in the case group was 6% and was not seen in the control group.

In the group given ibuprofen temperature was decreased more in measurement and in less time; in addition, patients who were given ibuprofen had more side effects such as diarrhoea, vomiting and abdominal pain.

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