Article Text

KAWASAKI DISEASE
  1. R Chabchoub Ben Abdallah1,
  2. A Bouraoui1,
  3. S Ben Ameur1,
  4. N Ben Halima1,
  5. M Ben Salah1,
  6. A Mahfoudh1
  1. 1Emergency Department and Paediatric Intensive Care Unit, Hedi Chaker Hospital, Sfax, Tunisia

Abstract

Introduction Our aim was to inform the clinical findings and evolution of 13 patients diagnosed with Kawasaki disease.

Patients and Methods Over a period of 6 years (January 2002–December 2007), Kawasaki disease was confirmed in 13 patients.

Results The median age at diagnosis was 2.5 years (range 1–5). The sex ratio was 3.33 (10 boys and three girls). A prolonged fever was observed in all cases. The major signs were observed in all children; indeed, all patients had at least four major signs. Biological evaluation showed leucocytosis in 10 children, thrombocythaemia in six children, a high level of C-reactive protein (>50 mg/l) and a high rate of sedimentation (>50 mm) in 11 children. Two children presented with hydrops of the gallbladder. The cardiac ultrasound performed in all patients objectified a single case of coronary anomaly (dilatation of the left coronary artery). Twelve children received intravenous immunoglobulin (2 g/kg) and all children received oral aspirin of 80–100 mg/kg per day in the acute febrile phase, which was followed by 3 to 5 mg/kg per day starting usually 1 or 2 days after fever subsided. The evolution was favourable in all cases: fever disappeared after 3.6 days of hospitalisation; the cardiac ultrasound performed after 6 months in nine patients proved to be normal.

Conclusion Kawasaki disease is essentially a disease of young children. Mortality linked to vascular complications has become very low through early diagnosis and treatment with immunoglobulin.

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