Article Text

SACCHARASE AND MALTASE ACTIVITY IN CHILDREN WITH INFLAMMATORY BOWEL DISEASES
  1. S Wiecek1,
  2. H Wos1,
  3. U Grzybowska-Chlebowczyk1,
  4. I Radziewicz-Winnicki1
  1. 1Department of Paediatrics, Silesian Medical University, Katowice, Poland

Abstract

Etiopathogenesis of Inflammatory Bowel Diseases (IBD) is very complex. So far, there are no definite links between ulcerative colitis and diet, but epidemiological studies have suggested that patients with Crohn's disease eat more sugar and sweets. The aim of the study was the evaluation of saccharase and maltase activity in patients with various forms of IBD.

Patients and Methods The study comprised 54 children, aged 3–18 years, in whom we diagnosed various forms of IBD: in 10 children- Crohn’s disease, in 15- ulcerative colitis, in 7- lymphocytic colitis, and in 22- undetermined colitis. During the endoscopy of the upper part of the alimentary tract we took biopsy specimens from the descending part of the duodenum. In these bioptates we determined saccharase and maltase activity using the Dahlquist’s method.

Results Decreased saccharase activity was most frequently observed in patients with lymphocytic colitis (in 4/7- 55%) and ulcerative colitis (7/15- 46%), whereas, the least frequently in children with undetermined colitis (in 8/22- 36%). Decreased maltase activity was most frequently observed in patients with Crohn’s disease (in 3/10- 30%), whereas, the least frequently in children with ulcerative colitis (in 2/15- 13%). The lowest mean values of maltase activity were found in the children with Crohn’s disease (5,4 U/1 g). The lowest mean values of saccharase activity were observed in patients with lymphocytic colitis and ulcerative colitis (2,7∼3,3 U/1 g)

Conclusions It seems reasonable to perform diagnostics examinations aimed at saccharase and maltase intolerance and to initiate the dietary treatment in children with IBD.

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