Objective 60 children aged 7–8 years were included into the study. The main group included 30 children and the control group used for comparison – 30 children.

The medication vitamin-mineral complex “Complivit Active” (Russia) was administered to the children of the main group (1 tablet once daily for 3 months). Informed consent of all parents was obtained. The medication contains all principal vitamins, microelements.

Methods Nasopharyngeal microflora was determined in all children. Besides, blood serum γ-interferon, vitamin A, E and C levels, salivary IgA, sIgA levels were determined.

Results All children had a depletion of micronutrient supplies. S. aureus nasopharyngeal carriage state was diagnosed in 68% of children. Blood serum γ-interferon and salivary IgA level were above, sIgA- lower the normal range in most children. Blood serum vitamins C and A levels were at the lower normal limit. Blood serum vitamin E, zinc and selenium levels were within the normal range. A relief of intoxication symptoms (p = 0.05) and vitamin deficiency (p = 0.05) was noted after the medication “Complivit Active” supplementation (RC = 0,42; CI = 0,14 to 1,29). Besides, improved, hemoglobin index (p = 0.001) increased, the incidence of S. aureus nasopharyngeal carrier states (p = 0.01) decreased, blood γ-interferon levels became normal (p = 0.01), vitamin A and E supplies increased (p = 0.01) and salivary IgA levels decreased and sIgA- increased (p = 0.05).

Conclusions Our findings suggest that positive changes in the health state of children are related to the positive polymodal effect of the vitamin-mineral complex on the mechanisms of host defence of the child.