Article Text

TROPONIN_I AND CARDIAC AUTOANTIBODIES VALUES FOR DETECTION OF CARDIOVASCULAR SYSTEM DAMAGE IN CHILDREN WITH RECURRENT RESPIRATORY TRACT DISEASES
  1. K Barabadze1,
  2. A Tsabutashbili2,
  3. S Rodonaia3
  1. 1Cathedra of Padiatrics, Tbilisi State University, Tbilisi, Georgia
  2. 2Institute of Pediatrics, Tbilisi State University, Tbilisi, Georgia
  3. 3Department of Cardio-Rheumatology, Tbilisi State University, Tbilisi, Georgia

Abstract

Objective Investigation of cardiac Tp-I and cardiac autoantibodies as a diagnostic markers for cardiovascular system impairments in children with recurrent respiratory system pathologies.

Methods 84 patients aged 3–15 years were examined. A cross-sectional study was held. Examination involvement criteria were as follows: children’s age (from 3 to 15). Pathological recurrent progressiveness of the respiratory system pathologies (5–7 episodes within the last year). Cardiac Troponin-I was measured in serum by ELISA. Cardiac autoantibodies were measured in serum applying immunofluorescence method.

Results In the patient of main group there were significant rise of Tp-I levels (0,127+−0,05). Cardiac autoantibody test was positive in 44%, which indicates on the autoimmunal feature of the disease.

Conclusions The study allows to use investigated markers as the diagnostic criteria of cardiovascular damage, which supports timely reveal the high risk group of the children with recurrent respiratory tract diseases; the study allows to manage disease, to held timely and adequate treatment and prevent from disabilities.

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