Article Text

DETECTION OF HIGH LEVELS OF HIV DRUG RESISTANCE IN CHILDREN ON HAART
  1. V F Eremin1,
  2. E L Gasich2,
  3. S V Eremin3,
  4. G V Lapizkaia,
  5. E I Kozorez
  1. 1Department of Clinical Virology, Research Institute for Epidemiology and Microbiology, Minsk, Belarus
  2. 2Minsk Children Infection Diseases Hospital, Minsk, Belarus
  3. 3Department of Infection Diseases, Gomel State Medical University, Gomel, Belarus

Abstract

Background Data on definition of mutations of a high level to NRTI and PI in children born to HIV-infected mothers are presented.

Methods Sequencing of 1.8 kb pol gene was performed using ABI Prism 3100 Avant, ViroSeq HIV-1 genotyping system software v2.6 (Stanford University Drug Resistance database) was used for interpretation of results.

Results Child S, 3 years old, born to an HIV-infected mother has been on HAART from 9 months, and receives AZT 3TC NVP. Researches by definition of resistance of HIV to ARV preparations have found a high level of resistance to NRTIs. The following mutations of resistance have been found: D67N, K70R, M184V, K219Q6; V118I - NRTI resistance mutations, as well as K101H, G190A - NNRTI resistance mutations. Child R, 3 years old, has been on HAART since August 2004. He has received PI+NRTIs. Research on resistance has revealed a high level of resistance to PI, as well as to NRTIs. The following mutations have been found: PI-M46I, L90M; NRTI-D67N, T69I, K70R, T215FY, K290Q. Child P, 14 years old, has been on HAART since 2004. Accepted PI+NRTIs. Research on resistance revealed a high level of resistance to PI and high level of resistance to NIRT: 3TC, ABC, AZT, D4T, DDI, FTC, TDF.

Conclusion Introduction of a method of detection of HIV resistance to ARV preparations in Belarus has allowed us to optimize approaches to the treatment of HIV infected patients, guiding changes in preparations and regimens for treatment. The resistance testing equipment has been obtained through donations from the Global Fund.

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