Article Text

FAMILY HISTORY AND RISK OF TYPE 1 DIABETES MELLITUS
  1. S Sipetic-Grujicic1,
  2. H Vlajinac1,
  3. N Kocev2,
  4. J Marinkovic2
  1. 1Institute of Epidemiology, School of Medicine, Belgrade University, Belgrade, Serbia
  2. 2Institute of Social Medicine, Statistics And Health Research, School of Medicine, Belgrade University, Belgrade, Serbia

Abstract

Objective The aim of the study was to evaluate association of type 1 diabetes in children with positive family history of type 1 diabetes, type 2 diabetes, thyroid, adrenal, rheumatic, allergic, coeliac and some other diseases.

Methods A case–control study was conducted in Belgrade. The case group comprised 105 children less than 17 years old who were hospitalized for the first time because of type 1 diabetes during the period 1994–1997. For each case two controls were chosen among children treated for skin diseases. Cases and controls were individually matched by age (± 1 year), sex and place of residence (all were from Belgrade). In the statistical analysis were used chi-squared test, Fisher exact test, and univariate and multivariate logistic regression.

Results According to multivariate logistic regression analysis, risk of type 1 diabetes was significantly associated with a positive family history for type 1 diabetes (OR 8.58; 95% CI 3.28 to 22.46), type 2 diabetes (OR 4.04; 95% CI 2.31 to 7.07), allergic diseases (OR 3.32; 95% CI 1.63 to 6.76), coeliac and Crohn’s disease (OR 11.02; 95% CI 1.14 to 106.89) and other diseases group (thrombocytopenia, alopecia areata, psoriasis, chronic uveitis and pernicious anemia; OR 3.63; 95% CI 1.05 to12.48).

Conclusions This study support the hypothesis that the risk of type 1 diabetes is increased in children with positive family history for type 1 diabetes.

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