Article Text

TESTING WILKIN’S ACCELERATION HYPOTHESIS IN A POPULATION AGED 2–14 YEARS IN UPPER SILESIA
  1. L Pracki1,
  2. P Jarosz-Chobot2,
  3. J Polanska1
  1. 1Silesian University of Technology, Gliwice, Slask, Poland
  2. 2Medical University of Silesia, Katowice, Poland

Abstract

Objective The aim of the study is to test the Wilkin’s acceleration hypothesis, predicting a relationship between age at diagnosis of type 1 diabetes and BMI or body weight.

Methods The study analyzed age, gender, BMI and body weight at onset for the cohort of 394 patients (223 boys) diagnosed at the age of 2>. Children were divided into age groups: 2–4, 5–9, and 10>. BMI and body weight (BW) were measured 30–90 days after onset, converted into SDS and then compared.

Results The mean values of SDS BMI, for all patients as well as separately for boys and girls were significantly lower than the general population (p<0.05; 95% CI −0.27 to −0.08, −0.32 to −0.07 and −0.29 to −0.01, respectively). These three groups’ mean SDS of body weight was significantly higher than the population (95% CI 0.34 to 0.56, 0.28 to 0.57 and 0.32 to 0.64). The SDS BMI of children from 2–4, 5–9 age groups were similar, with no dependence on gender. Children aged 10 (especially boys) had BMIs similar to the population average, though higher than the younger ones (p = 0.0076). The analysis of SDS BW demonstrated that the youngest children had significantly higher body weight at onset (p<0.05) than other age groups. The observation of lower BMI and higher BW can suggest significantly higher SDS for body height.

Conclusions The significantly higher body weight and lower BMI measured in the group of the youngest children may indicate that the onset age is correlated with the height of children.

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