Article Text

CYTOKINE RESPONSE IN PERINATAL HIPOXY
  1. D Šumanović-Glamuzina1,
  2. F Čulo2,
  3. G Horvat2,
  4. A Robović1,
  5. T Božić1,
  6. Z Kuzman1
  1. 1Department Of Pediatrics, Neonatology And Intensive Care, Mostar, Bosnia-Herzegovina
  2. 2Department Of Physiology, School Of Medicine, University Of Zagreb, Zagreb, Croatia

Abstract

Objective Concentrations of cytokines (IL-6, IL-1β, TNF-α, IL-18) in cerebrospinal fluid (CSF) and serum of hypoxic newborns (5 to 96 hours old) was determined and correlated with level of hypoxic-ischemic encephalopathy (HIE) and the neurological outcome in 12 month old children.

Subjects and Methods A prospective cohort analysis included 35 children with PNH. 25 children served as the control group. The cytokines were determined by ELISA assay. HIE was determined according to Sarnat/Sarnat method. Neurologic outcomes were estimated according to Amiel-Tison method

Results Mean concentration of IL-6 in serum was statistically higher in patients than in the control group (p = 0.0407). In the CSF concentrtrations were not significantly different. TNF-α was significantly higher in the serum (p = 0.023), not in CSF. IL-18 and IL-1β were unmeasurable in CSF in both groups. In serum the values were higher in patients, but not significantly. No significant correlation between the concentrations of mediators and neurologic outcome was found in the 12 month old infants.

Conclusion Inflammatory cytokines were present in serum and CSF of the newborns with PNH in the acute phase of disease. There was not any significant correlation of concentration of cytokines and the HIE stage with the neurological findings in the 12 month old infants.

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