Background HLA-DR is a MHC class II molecule responsible for antigen presentation to T-cells. Monocytes express HLA-DR molecules and low HLA-DR expression is a sign of immunosupression. We characterized moncyte HLA-DR expression in cord blood and during the first postnatal days in VLBW and near term infants.
Patients 18 VLBW infants (ga 24–29 wk, bw 750–1500 g) and 9 control infants ga >34 wk without main morbity (bw 1860–4020 g)
Methods Samples from cord vein, from VLBW infants on d 1.3 and 7, and from controls on d 1. Monocytes were labelled with CD14FITC and HLA-DR PE and analyzed with FACS.
Results After birth HLA-DR decreased significantly more in VLBW infants than in controls (Figure).