Article Text

POSTNATAL DECREASE IN HLA-DR EXPRESSION ON CIRCULATING MONOCYTES
  1. A Palojarvi1,
  2. J Petaja1,
  3. I Nupponen1,
  4. C Janer1,
  5. H Repo2,
  6. S Siitonen3,
  7. S Andersson1
  1. 1Hospital for Children and Adolescents, Helsinki University Hospital, Helsinki, Finland
  2. 2Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland
  3. 3Department of Hemotology, Helsinki University Hospital, Helsinki, Finland

Abstract

Background HLA-DR is a MHC class II molecule responsible for antigen presentation to T-cells. Monocytes express HLA-DR molecules and low HLA-DR expression is a sign of immunosupression. We characterized moncyte HLA-DR expression in cord blood and during the first postnatal days in VLBW and near term infants.

Patients 18 VLBW infants (ga 24–29 wk, bw 750–1500 g) and 9 control infants ga >34 wk without main morbity (bw 1860–4020 g)

Methods Samples from cord vein, from VLBW infants on d 1.3 and 7, and from controls on d 1. Monocytes were labelled with CD14FITC and HLA-DR PE and analyzed with FACS.

Results After birth HLA-DR decreased significantly more in VLBW infants than in controls (Figure).

Discussion

Low HLA-DR expression may be associated with immaturity and morbidity in VLBW infants.

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