Objective Although breastfeeding has been associated with a protective effect against metabolic syndrome, little is known about the association between the types and duration of infant feeding and serum adipocytokines.
Design and methods Serum adiponectin (Ad), leptin (Lep), total cholesterol (TC), and low density lipoprotein cholesterol (LDLc) were measured longitudinally at birth, 6 and 12 months after birth in 46 healthy infants. They were classified into two groups based on whether or not they were breastfed until 12 months of life: Group A, 35 infants received breastfeeding for 6 months or more regardless of supplementation of cow’s milk-based formula, and Group B, 11 infants received breastfeeding for less than 6 months.
Results Serum TC at 12 months was significantly higher in Group A than that in Group B. There was no significant difference in anthropometric measurements, serum Ad and Lep between two groups. The duration of breastfeeding had a significant positive correlation with serum TC and LDLc at 12 months. Serum Ad at 12 months had a strong positive correlation with cord blood Ad, and its relationship was not affected by infant-feeding.
Conclusion Our data suggest that there is no relationship between types and duration of infant feeding and serum adiponectin and leptin but serum cholesterol in infants breastfed at least for 6 months may be higher at 12 months. It remains to be investigated to what extent adiponectin in the umbilical blood has an effect and whether it is involved in the development of metabolic syndrome.