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EFFECT OF ANTENATAL MAGNESIUM SULFATE ADMINISTRATION ON BIOCHEMICAL PARAMETERS OF RED CELLS MEMBRANE IN VLBW NEONATES
  1. E M Gulczyńska1,
  2. J Gadzinowski1,
  3. B Pawłowska1,
  4. M Nowiczewski1,
  5. L Żylińska2
  1. 1Department of Neonatology, Research Institute of Polish Mother’s Memorial Hospital, Lodz, Poland
  2. 2Department of Molecular Neurochemistry, Medical University of Lodz, Lodz, Poland

Abstract

Objective MgSO4 is widely used during pregnancy in PIH and as a tocolytic drug.

Some authors emphasize that MgSO4 given antenatally could act as a neuroprotective factor in VLBWN. The aim of this study was to compare the selected parameters including: ATP concentration, band 3 amount, TBARS concentration and phosphotyrosine content in erythrocyte membranes of preterm newborn whose mothers were treated or untreated with MgSO4.

Methods The study group consist of 24 neonates prenatally exposed to MgSO4 (BW⩽1500 g and GA⩽34 weeks). Control group included 20 infants (without prenatal Mg2+ administration). In both groups, blood at time 0 and 24 h later was collected with citrate and erythrocyte ghosts were prepared.

Results In erythorocyte membranes of the study group TBARS at 0 and the 24th hours of life were nearly twice as low in comparison with the control group. Directly after birth the ATP concentrations in the study group were lower by 24% compared to control group. In the study group a lower quantity of chloride channel protein was revealed. Tyrosine phosphorylation of chloride channel monomeric forms was similar in both groups just after birth while phosphorylation levesl increased by 20% after 24 hours of life in the control group.

Conclusions The results presented belong to the first trials to explain the mechanisms of the influence of magnesium on the fetus and newborn organism.

The project was funded by grant no. PBZ-MEiN-/8/2//2006 financed by Polish Ministry of Science and Higher Education.

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