Article Text

COMPARISON OF THE SCLEROGENIC EFFECT BETWEEN TWO SUBSTANCES IN THE TREATMENT OF LABIAL VENOUS MALFORMATIONS IN YOUNG ADOLESCENTS AND CHILDREN
  1. BE Sari1,
  2. M Aribi2
  1. 1Pathology and Oral Surgery Department, University Medical Centre of Tlemcen and Toxicomed Laboratory, Faculty of Medical Sciences, Abou-Bekr Belkaid University of Tlemcen, Tlemcen, Algeria
  2. 2Toxicomed Laboratory, Faculty of Medical Sciences, Abou-Bekr Belkaid University of Tlemcen, Tlemcen, Algeria

Abstract

Objective Vascular venous malformations are present at birth, and evolve progressively, yet slowly. They are generally located in the cervico-cephalic region, and are responsible for functional disorders and aesthetics and consequently for psychological repercussiona in adolescent subjects. Their treatment includes two consecutive steps. A pre-surgical one or sclerotherapy, which consists of many trans-mucous embolisations using a sclerogenic agent, and a surgical one.

Aim To compare the therapeutic effect between two sclerogenic substances, 3% sodium tetradecyl sulfate and absolute alcohol among young patients with a labial vascular malformation (LVM).

Methods Five patients whose mean age in the evolutionary peak is 12±1 years (range: 11–13 years) were recruited at the Pathology and Oral Surgery Department of University Medical Centre of Tlemcen (northwest of Algeria) for a randomised clinical trial. The sclerogenic effect is evaluated through fibrose installation speed (lesion drying) related to injection number, clinically translated by an induration at the lesion palpation and by the absence of increase in its volume in the sloping position (surgery time determining factors).

Results The number of injections (1 mL/injection) of sodium tetradecyl sulfate was considerably higher than that of absolute alcohol (3% sodium tetradecyl sulfate: injections number  = 7.5±0.7 (range: 7–8); absolute alcohol: injections number  = 5.7±0.6 (range: 5–6), p<0.05).

Conclusions This study showed that the sclerogenic action of absolute alcohol is higher than that of the sodium tetradecyl sulfate. Additionally, no case of cutaneo-mucous necrosis was observed.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.