Objective Vascular venous malformations are present at birth, and evolve progressively, yet slowly. They are generally located in the cervico-cephalic region, and are responsible for functional disorders and aesthetics and consequently for psychological repercussiona in adolescent subjects. Their treatment includes two consecutive steps. A pre-surgical one or sclerotherapy, which consists of many trans-mucous embolisations using a sclerogenic agent, and a surgical one.
Aim To compare the therapeutic effect between two sclerogenic substances, 3% sodium tetradecyl sulfate and absolute alcohol among young patients with a labial vascular malformation (LVM).
Methods Five patients whose mean age in the evolutionary peak is 12±1 years (range: 11–13 years) were recruited at the Pathology and Oral Surgery Department of University Medical Centre of Tlemcen (northwest of Algeria) for a randomised clinical trial. The sclerogenic effect is evaluated through fibrose installation speed (lesion drying) related to injection number, clinically translated by an induration at the lesion palpation and by the absence of increase in its volume in the sloping position (surgery time determining factors).
Results The number of injections (1 mL/injection) of sodium tetradecyl sulfate was considerably higher than that of absolute alcohol (3% sodium tetradecyl sulfate: injections number = 7.5±0.7 (range: 7–8); absolute alcohol: injections number = 5.7±0.6 (range: 5–6), p<0.05).
Conclusions This study showed that the sclerogenic action of absolute alcohol is higher than that of the sodium tetradecyl sulfate. Additionally, no case of cutaneo-mucous necrosis was observed.