Ménétrier’s disease is an uncommon disease in childhood characterized by enlarged gastric rugal folds and gastric mucosal thickening and hypoproteinemia secondary to a protein-losing gastroenteropathy. In this report we present the second case of Ménétrier’s disease in a child with co-infection of cytomegalovirus (CMV) and Helicobacter pylori (H. pylori).
Case report A 12 month-old boy was admitted with a two week history of oedema of the face and extremities associated with vomiting. Urine analyses were normal. Protein losing enteropathy was confirmed by laboratory investigations: hypoalbuminemia, hypoproteinemia and eleved fecal alpha1 antitrypsin. Diagnosis of Ménétrier’s disease was suspected by the presence of thick gastric folds on gastric ultrasound and gastrointestinal endoscopy and confirmed by histological study. Aetiological investigations revealed co-infection of CMV and H. pylori. After the eradication therapy against H. pylori, we observed clinical, biochemical and ultrasonographic resolution of the disease.
Conclusion Intractable Ménétrier’s disease with CMV infection may associate with H. pylori infection. In such a case, eradication therapy of H. pylori may contribute to clinical resolution.