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IMPROVED RECOVERY FROM COWSâ MILK ALLERGY COLITIS WITH LACTOBACILLUS GG COMPARED WITH EXTENSIVELY HYDROLYSED FORMULA ALONE
  1. M Baldassarre1,
  2. N Laforgia1,
  3. R Grosso1,
  4. A Laneve1,
  5. M Fanelli2,
  6. A Altomare3,
  7. C Lifschitz4,5
  1. 1Dip Ginec Ost E Neonat, U O Neonat E TIN, University of Bari, Bari, Italy
  2. 2Dip Med Int E Pub, Sez Diagn Imag, Bari, Italy
  3. 3Dip Biomed Eta Evolut, Bari, Italy
  4. 4Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
  5. 5Mead Johnson Nutritionals, Evansville, Indiana, USA

Abstract

Introduction Cows’ milk allergy (CMA), a cause of haematochezia in infants, is resolved with an extensively hydrolysed formula (EHF). Fecal calprotectin, a neutrophil-derived protein is a marker of intestinal inflammation. Lactobacillus GG (LGG) improves symptoms of atopic dermatitis caused by CMA.

Objective Compare recovery from CMA between an EHF, nutramigen versus nutramigen with LGG.

Methods Twenty-six infants with haematochezia (group A) (mean age 4.1 months) were randomly assigned in a double-blind manner to nutramigen LGG (12) or nutramigen without LGG (14). Group B: age-matched, healthy controls.

Results At diagnosis fecal calprotectin in group A was significantly higher than in group B (mean 328 vs 132 μg/g, p<0.001). At 4 weeks, fecal calprotectin in group A had decreased to one half but was still significantly higher than in group B (159 vs 94, p<0.03) and none of the infants in the nutramigen LGG group had occult blood in stools, whereas 5/14 in the nutramigen group did (p = 0.002). Mean fecal calprotectin in the nutramigen LGG (68) was significantly lower than in the nutramigen group (286) (p = 0.0008).

Conclusion In CMA colitis nutramigen LGG resulted in a significant reduction of haematochezia and markers of intestinal inflammation compared with nutramigen alone.

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