Introduction Cows’ milk allergy (CMA), a cause of haematochezia in infants, is resolved with an extensively hydrolysed formula (EHF). Fecal calprotectin, a neutrophil-derived protein is a marker of intestinal inflammation. Lactobacillus GG (LGG) improves symptoms of atopic dermatitis caused by CMA.
Objective Compare recovery from CMA between an EHF, nutramigen versus nutramigen with LGG.
Methods Twenty-six infants with haematochezia (group A) (mean age 4.1 months) were randomly assigned in a double-blind manner to nutramigen LGG (12) or nutramigen without LGG (14). Group B: age-matched, healthy controls.
Results At diagnosis fecal calprotectin in group A was significantly higher than in group B (mean 328 vs 132 μg/g, p<0.001). At 4 weeks, fecal calprotectin in group A had decreased to one half but was still significantly higher than in group B (159 vs 94, p<0.03) and none of the infants in the nutramigen LGG group had occult blood in stools, whereas 5/14 in the nutramigen group did (p = 0.002). Mean fecal calprotectin in the nutramigen LGG (68) was significantly lower than in the nutramigen group (286) (p = 0.0008).
Conclusion In CMA colitis nutramigen LGG resulted in a significant reduction of haematochezia and markers of intestinal inflammation compared with nutramigen alone.