Article Text

  1. B Isik1,
  2. O Baygin2,
  3. H Bodur2
  1. 1Oral and Maxillofacial Surgery Department, Gazi University Faculty of Dentistry, Ankara, Turkey
  2. 2Pediatric Dentistry Department, Gazi University Faculty of Dentistry, Ankara, Turkey


Aim Sedation at the desired level might not be achieved despite the administration of various agents. We aim to evaluate the effectiveness of oral premedication with different agents on children scheduled for dental treatment under nitrous oxide/oxygen (N2O/O2) sedation.

Methods After ethics committee approval and parental informed consent, 60 healthy children aged between 5 and 8 years, having no sedation or general anaesthesia experience and incompliant with dental treatment (Frankl behaviour scale ⩾3) were enrolled into this study. Children were randomly assigned to four groups. The treatment regimes were as follows: oral administration of 1 mg/kg hydroxizine hydrochloride suspension 1 h preoperatively (group I, n  =  15); oral administration of 0.7 mg/kg midazolam HCl 15 minutes preoperatively (group II, n  =  15); oral administration of 3 mg/kg ketamine + 0.25 mg/kg midazolam HCl 15 minutes preoperatively (group III, n  =  15) and no oral premedication was administered to the control group (group IV, n  =  15). Following premedication, 40% N2O and 60% O2 were administered to all groups. Sedation depth was evaluated using the Houpt sedation scale and Ramsay sedation scale and data were recorded at 5-minute intervals. Anxiety and sedation levels, recovery time of children in addition to satisfaction of parents, dentist and anaesthesiologist were recorded postoperatively. Data were statistically analysed with analysis of variance, Kruskal–Wallis, χ2 and Friedman tests (p<0.05).

Results Achievement of sedation in terms of satisfactory/middle level satisfactory/unsatisfactory was as follows, respectively: 13.3%/33.3%/54% in group I, 54%/20%/26% in group II, 33.3%/33.3%/33.3% in group III and 6.7%/60%/33.3% in group IV.

Conclusion 0.7 mg/kg midazolam is more effective than the other groups in children scheduled for dental treatments.

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.