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P1 HEALTH OF CHILDREN BORN AFTER PREIMPLANTATION GENETIC DIAGNOSIS: AN INITIAL STUDY

1I Banerjee, 1R Tozer, 3J Barnes, 2M Shevlin, 1K Johnson, 1A Sutcliffe. 1Institute of Child Health, University College London, London, UK; 2University of Ulster, Londonderry, UK; 3Institute for the Study of Children, Families and Social Issues, Birkbeck, University of London, London, UK

Aims: The use of preimplantation genetic diagnosis (PGD) is rapidly expanding as a diagnostic technique. As it involves in-vitro fertilisation and usually intracytoplasmic sperm injection, the health of children born after PGD is proposed to have similarities with those born after conventional in-vitro fertilisation and intracytoplasmic sperm injection therapy. Indeed this is borne out by the limited literature on paediatric outcome, almost entirely (uncontrolled) birth data from the ESHRE consortium.

Methods: A cross-sectional, population controlled, study was conducted. Five centres with established PGD programmes in London were contacted to participate, of which four agreed to help recruit patients. Children who were aged up to 4 years and their parents were assessed by a single observer blinded to their conception status in a child-friendly outpatient setting. Naturally conceived children were recruited from local nurseries for the control group. The London-based Multiple Birth Foundation was approached for recruitment of twin controls. Children who had emigrated, who were born at less than 32 weeks’ gestation or whose mother tongue was not English were not approached. Control children were matched for age, sex, multiplicity, ethnicity, maternal educational level and socioeconomic status.

Results: 49 children were assessed with 66 matched naturally conceived control children. The primary outcome measure was neurodevelopmental scoring and the secondary outcome measures were family functioning and any (initial) evidence of growth problems or other physical abnormalities. Growth parameters at mean age 18 months were normal. The mean Griffiths quotient was 102.7 (±13.1) (PGD) and 103.3 (±12.8) (naturally conceived), which were …

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