Article Text

PDF
Weight gain with pizotifen therapy
  1. G L Briars,
  2. S E Travis,
  3. B Anand,
  4. A M Kelly
  1. Department of Paediatrics, West Suffolk Hospital, Bury St Edmunds, UK
  1. Dr G L Briars, Department of Paediatrics, West Suffolk Hospital, Hardwick Lane, Bury St Edmunds IP33 2QZ, UK; g.briars{at}doctors.org.uk

Abstract

Objective: To describe the characteristics of weight gain occurring in children treated for migranous conditions with pizotifen

Design: Retrospective case note review

Setting: West Suffolk Hospital between 1999 and 2003

Patients: 405 clinic attendances of 121 children receiving pizotifen treatment

Main outcome measures: Rates of change in weight for age z score between successive outpatient appointments were used to detect excessive weight gain.

Results: The mean rate of weight z score increase for 105 patients receiving a constant dosage in 181 intervals between appointments was 0.79 standard deviations per year compared with 0.11 standard deviations per year for height z score increases. The rate of weight z score increase was not correlated with pizotifen dose per kg (r = −0.08), per m2 (r = −0.05) or initial body mass index (r = −0.04). Mean rates of z score increase were similar in patients with a satisfactory and unsatisfactory therapeutic responses.

Conclusions: Excess weight gain in pizotifen therapy is not predicted by drug dosage or therapeutic response within the range of doses used in clinical practice.

Statistics from Altmetric.com

Footnotes

  • Competing interests: None.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.