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Angiotensin II receptor blockers to slow aortic root dilation in Marfan’s syndrome

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Marfan’s syndrome is an autosomal dominant condition affecting about 1 in 5000 people and is caused by mutations in the gene (FBN1) that encodes fibrillin-1. The main cause of premature death in people with Marfan’s syndrome is progressive dilation of the aortic root leading to dissection. Current medical treatment is mainly with β blockers. Experiments …

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