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An audit of lymphopenia in infants under 3 months of age
  1. M T Krishna1,
  2. J L Tarrant2,
  3. E A Cheadle2,
  4. S Noorani1,
  5. S Hackett3,
  6. A P Huissoon1
  1. 1
    Department of Immunology, Birmingham Heartlands Hospital, Birmingham, UK
  2. 2
    Medical School, University of Birmingham, Birmingham, UK
  3. 3
    Department of Paediatrics, Birmingham Heartlands Hospital, Birmingham, UK
  1. Dr M T Krishna, Department of Immunology, Bordesley Green East, Birmingham B9 5SS, UK; mtkrishna{at}yahoo.com

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Severe combined immunodeficiency (SCID) describes a group of rare genetic disorders characterised by deficient or absent T cell immunity, with an estimated incidence of 1 in 50 000 to 1 in 500 000.1 SCID is considered a paediatric emergency, but early clues, such as lymphopenia, are often not noted.2 As a result, the UK Primary Immunodeficiency Network (UK PIN) recommends that children under 2 years of age with an absolute lymphocyte count (ALC) below 3000/μl must be screened for SCID.3

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