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Arch Dis Child 92:827 doi:10.1136/adc.2007.119909
  • Letter

Avidity of Haemophilus influenzae type b antibody in UK infants

  1. Janet E Berrington1,
  2. Alan C Fenton1,
  3. Konstantinos Arnaoutakis2,
  4. Q Zhang2,
  5. Adam Finn2
  1. 1
    Department of Neonatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
  2. 2
    Institute of Child Life and Health, UBHT Education Centre, Bristol University, Bristol, UK
  1. Janet E Berrington, Department of Neonatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK; janet.berrington{at}nuth.nhs.uk

    Preterm infants have been shown to respond with lower antibody levels of protective anti-polyribisolribitolphosphate (PRP) to immunisation against Haemophilus influenzae type b (Hib) than term infants. This may be particularly relevant in the UK where fourth doses of Hib vaccine were not given until September 2006, and preterm infants were at increased risk of Hib disease. Other measures such as antibody avidity may give valuable information. …