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Postprandial hyperinsulinaemic hypoglycaemia and type 1 diabetes mellitus
  1. Myra Poon,
  2. Khalid Hussain
  1. London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, London, UK
  1. Correspondence to:
    Dr K Hussain
    Developmental Endocrinology Research Group, Molecular Genetics Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK; K.Hussain{at}


A patient with severe postprandial hyperinsulinaemic hypoglycaemia (PPHH) for 4 years developed type 1 diabetes mellitus. She had no insulin or insulin receptor antibodies but was positive for islet cell and glutamic acid decarboxylase (GAD) antibodies. PPHH prior to the onset of type 1 diabetes mellitus has not been previously described and may be a prodrome of type 1 diabetes mellitus.

  • DM, diabetes mellitus
  • GAD, glutamic acid decarboxylase
  • IAS, insulin autoimmune syndrome
  • OGTT, oral glucose tolerance test
  • PPHH, postprandial hyperinsulinaemic hypoglycaemia

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  • Competing interests: None.

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