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We read with interest the stimulating comments by Dr Wjst1 concerning our prebiotic study in infants at risk for allergy.2
Because this was the first study using prebiotics for the prevention of atopic dermatitis, our statistical consultant proposed that the p value should be calculated “conservatively”. However, we agree that the single-sided test is more appropriate, which indeed changes the p value from 0.014 (as given in the paper) to 0.008.
We were aware of the fact that the risks by parental history of various allergic diseases are not interchangeable, as described in the paper by Dold et al.3 We recorded the allergic diseases of the parents. There was …