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Splenectomy in cystic fibrosis remains controversial, mainly because the spleen is considered indispensable in this disease for its important immunological function in defence against frequent infections. Furthermore, centres that perform liver transplantation prefer this approach even after early cystic fibrosis-related liver disease becomes obvious, as it seems more aetiological.
The article by Linnane et al1 is an interesting contribution to this debate. Our recently published findings2 largely confirm that article although we have doubts on the correctness of the …