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The leading cause of preterm delivery in the world is pre-eclampsia. Some 3–5% of pregnancies are complicated by pre-eclampsia, and it is a major factor in maternal and neonatal morbidity and mortality. Endothelial dysfunction seems to be a fundamental problem in pre-eclampsia, and recent animal and human research on proangiogenic and antiangiogenic proteins has raised hopes of understanding, predicting, and even preventing or treating the condition.
The research has concentrated …