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Prophylactic fluconazole for very low birthweight infants

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Colonisation rates of up to 60% for candida species have been reported among very low birthweight (VLBW, <1500 g) infants in neonatal intensive care units (NICUs). Invasive fungal infection may develop in up to 20% of these children. The report of a single-centre trial published in 2001 showed that prophylactic fluconazole reduced candida colonisation and invasive infections among extremely low birthweight (<1000 g) neonates. Now …

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