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G146 LONGITUDINAL CHANGES IN LOWER LIMB LENGTH AND TIBIAL SPEED OF SOUND IN PRETERM INFANTS: RELATIONSHIP WITH GESTATION, BIRTH WEIGHT STANDARD DEVIATION SCORE, AND BONE NUTRIENTS

J. E. Mercy1, B. Dillon2, J. Morris2, A. J. B. Emmerson3, M. Z. Mughal4.1Neonatal Medicine St Mary’s Hospital for Women and Children, Manchester, UK; 2Department of Medical Statisics, University of Manchester, Manchester, UK; 3Neonatal Medicine, St Mary’s Hospital for Women and Children, Manchester, UK; 4Paediatric Medicine, St Mary’s Hospital for Women and Children, Manchester, UK

We measured lower limb length (LLL) (mm) using an electronic neonatal knemometer and tibial speed of sound (tSOS) (m/s; related to bone mineralisation and elasticity), using the Sunlight Omnisense 7000 quantitative ultrasound device, in the same limb, weekly for a median period of four weeks (range 2–14 weeks) in 84 preterm infants. The median (range) gestation and birth weight of infants was 26.8 weeks (23–35.2 weeks) and 869.5 g (418–1481 g), respectively. Birth weight standard deviation scores (BwSDS) were negatively associated with gestation (r = −0.456; p = 0.001), suggesting that older babies had a tendency to be growth retarded. LLL increased (within-subject correlation, r = 0.96; p<0.001) whereas tSOS (within-subject correlation, r = −0.15; p = 0.011) decreased with postnatal age. The rate of postnatal increase in LLL but not the change in tSOS was positively influenced by intake of calcium (p = 0.030), phosphorous (p = 0.012), and vitamin D (p = 0.030). Gestation was associated with both the initial LLL (r = 0.757; p<0.001) and tSOS (r = 0.42; p<0.001) but not their rate of change. BwSDS scores were significantly related to initial tSOS (r = −0.38, p = 0.001) but not LLL measurements, suggesting that infants with low BwSDS had a higher initial SOS value compared to those with higher BwSDS. However, as …

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