Arch Dis Child 91:793-794 doi:10.1136/adc.2006.098962
  • Archimedes

Should metformin be prescribed to overweight adolescents in whom dietary/behavioural modifications have not helped?

  1. E Webb1,
  2. R Viner2
  1. 1University College Hospital, London, UK;
  2. 2Institute of Child Health, University College London, UK

    An obese, 12 year old girl comes for review in clinic. A year ago when you first saw her you gave comprehensive advice regarding dietary modification, and exercise. She has continued to gain weight with a BMI greater than the 99th centile. You arrange for an oral glucose tolerance test to be performed which shows her to be hyperinsulinaemic with fasting insulin of 20 mIU/l, and 120 min insulin of 200 mIU/l. She has normal fasting and 120 min blood glucose measurements. You wonder whether prescribing metformin may help her to lose weight.

    Structured clinical question

    In obese hyperinsulinaemic adolescents [patient] is metformin [intervention] effective in promoting weight loss [outcome]?

    Search strategy and outcome

    Secondary (Cochrane library, 2004) and primary (Medline, Embase) sources were included in the search.

    Search strategy: “Obesity” AND “Adolescent” AND “Metformin”.

    Search outcome: 276 hits (14; 61; 201; each search respectively), of which 2 (2; 2; 0) studies were directly relevant to this question. …