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New insights into pulmonary inflammation in cystic fibrosis
  1. S Rao1,
  2. J Grigg2
  1. 1Department of Respiratory Medicine and Cystic Fibrosis, Birmingham Children’s Hospital NHS Trust, Steelhouse Lane, Birmingham B4 6NH, UK
  2. 2Institute of Cell and Molecular Science, Barts and The London, Queen Mary’s School of Medicine and Dentistry, London, UK
  1. Correspondence to:
    Dr J Grigg
    Institute of Cell and Molecular Science, Barts and The London, Queen Mary’s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK; j.grigg{at}qmul.ac.uk

Abstract

Persistent lower airway infection with inflammation is the major cause of morbidity and mortality in cystic fibrosis. This review examines the recent advances in the understanding of airway inflammation in cystic fibrosis, and focuses on the evidence that pulmonary inflammation is, under some circumstances, disassociated from infection, and the potential implications for therapeutic intervention.

  • cystic fibrosis
  • infection
  • inflammation

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Footnotes

  • Competing interests: none

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