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Inhaled hypertonic saline in cystic fibrosis

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In the lungs of patients with cystic fibrosis there is excessive absorption of sodium and defective secretion of chloride across the respiratory epithelium. This leads to extra water absorption, drying of airway contents, and inspissation of mucus, with defective mucociliary function and consequent liability to infection. Now researchers in Australia (

; see also editorial, ibid: 291–3) and the USA (Scott H Donaldson and colleagues. Ibid: …

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